Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Bart Frank
PROVIDER: E-GEOD-40982 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Ma Hongwei H Thapa Arjun A Morris Lynsie M LM Michalakis Stylianos S Biel Martin M Frank Mark Barton MB Bebak Melissa M Ding Xi-Qin XQ
Human molecular genetics 20130604 19
The cone photoreceptor cyclic nucleotide-gated (CNG) channel is essential for central and color vision and visual acuity. Mutations in the channel subunits CNGA3 and CNGB3 are associated with achromatopsia and cone dystrophy. We investigated the gene expression profiles in mouse retina with CNG channel deficiency using whole genome expression microarrays. As cones comprise only 2 to 3% of the total photoreceptor population in the wild-type mouse retina, the mouse lines with CNG channel deficienc ...[more]