Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Joan Brugge
PROVIDER: E-GEOD-40986 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Cancer cell 20130601 6
Breast cancer is a heterogeneous disease and can be classified based on gene expression profiles that reflect distinct epithelial subtypes. We identify prostate-derived ETS factor (PDEF) as a mediator of mammary luminal epithelial lineage-specific gene expression and as a factor required for tumorigenesis in a subset of breast cancers. PDEF levels strongly correlate with estrogen receptor (ER)-positive luminal breast cancer, and PDEF transcription is inversely regulated by ER and GATA3. Furtherm ...[more]