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Differential roles for MBD2 and MBD3 at methylated CpG islands, active promoters and exon sequences

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Marek Bartkuhn

PROVIDER: E-GEOD-41010 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Differential roles for MBD2 and MBD3 at methylated CpG islands, active promoters and binding to exon sequences.

Günther Katharina K Rust Mareike M Leers Joerg J Boettger Thomas T Scharfe Maren M Jarek Michael M Bartkuhn Marek M Renkawitz Rainer R

Nucleic acids research 20130129 5

The heterogeneous collection of nucleosome remodelling and deacetylation (NuRD) complexes can be grouped into the MBD2- or MBD3-containing complexes MBD2-NuRD and MBD3-NuRD. MBD2 is known to bind to methylated CpG sequences in vitro in contrast to MBD3. Although functional differences have been described, a direct comparison of MBD2 and MBD3 in respect to genome-wide binding and function has been lacking. Here, we show that MBD2-NuRD, in contrast to MBD3-NuRD, converts open chromatin with euchro ...[more]

PMID: 23361464

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