Transcriptional profiling of hypoxic cells and identification of HEXIM1-dependent genes.
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ABSTRACT: To identify primary response genes (PRGs) that were differently expressed within 1 hr of hypoxia exposure, we performed global transcriptional profiling using the Agilent Technologies SurePrint G3 Human GE Microarray . To identify Hexim1-dependent genes, we compare profiles of hypoxia PRGs in cells transfected with control or Hexim1 targeting double-strand siRNA HeLa cells were transfected with control and HEXIM1-targeted double-strand siRNA and 48 hr after treated with IL-1beta in combination with normoxia or hypoxia (5% CO2, 0.5% O2, balanced with N2) O for 1 hr.
ORGANISM(S): Homo sapiens
SUBMITTER: Olga Safronova
PROVIDER: E-GEOD-41023 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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