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Integrative genomic characterization of oral squamous cell carcinoma identifies frequent somatic drivers (microRNA)

ABSTRACT: Oral cavity squamous cell carcinoma (OSCC) is a disease with extensive morbidity and mortality and few useful molecular targets. Multiplatform integrated genomic analysis was performed in order to identify genomic drivers and molecularly discernible tumor subtypes. mRNA, miRNA and methylation data are all submitted to GEO We measured microRNA expression of 43 OSCC cases with Agilent Human miRNA microarray rel12.0

ORGANISM(S): Homo sapiens

SUBMITTER: Jiexin Zhang

PROVIDER: E-GEOD-41115 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Integrative genomic characterization of oral squamous cell carcinoma identifies frequent somatic drivers (mRNA)

Project description:Oral cavity squamous cell carcinoma (OSCC) is a disease with extensive morbidity and mortality and few useful molecular targets. Multiplatform integrated genomic analysis was performed in order to identify genomic drivers and molecularly discernible tumor subtypes. mRNA, miRNA and methylation data are all submitted to GEO We measured gene expression of 43 OSCC cases with the Affymetrix Human Exon 1.0 ST Array

2013-01-01 | E-GEOD-41116 | biostudies-arrayexpress

Integrative genomic characterization of oral squamous cell carcinoma identifies frequent somatic drivers (methylation)

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2013-01-01 | E-GEOD-41114 | biostudies-arrayexpress

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Integrative genomic characterization of oral squamous cell carcinoma identifies frequent somatic drivers (methylation)

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Integrative genomic characterization of oral squamous cell carcinoma identifies frequent somatic drivers

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-01-01 | E-GEOD-41117 | biostudies-arrayexpress

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Project description:Gene Expression Profiling of Oral Squamous Cell Carcinoma (OSCC) was performed to delineate candidate genes clusters with potential to distinguish normal and tumor tissue from oral cavity. All tissue samples were collected after obtaining written informed consent. The RNA profile of 27 OSCC patients was compared with 4 independent controls and 1 pooled control oral cavity tissue from healthy donors. Agilent one-color experiment, Organism: Human, Agilent-014850 Whole Human Genome Microarray 4x44K G4112F

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Project description:The critical role of the tumor immune microenvironment (TIME) in determining response to immune checkpoint inhibitor (ICI) therapy underscores the importance of understanding cancer cell–intrinsic mechanisms driving immune-excluded (“cold”) TIMEs. One such cold tumor is oral cavity squamous cell carcinoma (OSCC), a tobacco-associated cancer with mutations in the TP53 gene which responds poorly to ICI therapy. Because altered TP53 function promotes tumor progression and plays a potential role in TIME modulation, here we developed a syngeneic OSCC models with defined Trp53 (p53) mutations and characterized their TIMEs and degree of ICI responsiveness. We observed that a carcinogen-induced p53 mutation promoted a cold TIME enriched with immunosuppressive M2 macrophages highly resistant to ICI therapy. p53-mutated cold tumors failed to respond to combination ICI treatment; however, the combination of a programmed cell death protein 1 (PD-1) inhibitor and stimulator of interferon genes (STING) agonist restored responsiveness. These syngeneic OSCC models can be used to gain insights into tumor cell–intrinsic drivers of immune resistance and to develop effective immunotherapeutic approaches for OSCC and other ICI-resistant solid tumors.

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Development of microRNA (miRNA) expression signatures for human glioma-initiating cells (GICs)

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Development of microRNA (miRNA) expression signatures for mouse glioma-initiating cells (GICs)

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2015-04-07 | E-GEOD-61080 | biostudies-arrayexpress

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