Unknown,Transcriptomics,Genomics,Proteomics

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1,25-dihydroxyvitamin D3-induced genes in mouse mixed neuron-glial cell cultures


ABSTRACT: Transcriptomic response of mouse mixed neuron-glial cell cultures to 1,25-dihydroxyvitamin D3 6 samples are analysed with three biological replicates in two conditions, control versus 1,25-dihydroxyvitamin D3 (1,25(OH)2D3)

ORGANISM(S): Mus musculus

SUBMITTER: didier wion 

PROVIDER: E-GEOD-41184 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

The transcriptomic response of mixed neuron-glial cell cultures to 1,25-dihydroxyvitamin d3 includes genes limiting the progression of neurodegenerative diseases.

Nissou Marie-France MF   Brocard Jacques J   El Atifi Michèle M   Guttin Audrey A   Andrieux Annie A   Berger François F   Issartel Jean-Paul JP   Wion Didier D  

Journal of Alzheimer's disease : JAD 20130101 3


Seasonal or chronic vitamin D deficiency and/or insufficiency is highly prevalent in the human population. Receptors for 1,25-dihydroxyvitamin D3, the hormonal metabolite of vitamin D, are found throughout the brain. To provide further information on the role of this hormone on brain function, we analyzed the transcriptomic profiles of mixed neuron-glial cell cultures in response to 1,25-dihydroxyvitamin D3. 1,25-dihydroxyvitamin D3 treatment increases the mRNA levels of 27 genes by at least 1.9  ...[more]

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