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Potentiation of regulatory T cell stability and function via a neuropilin-1:semaphorin-4a axis

ABSTRACT: Regulatory T cells (Treg) represent a critical immunoregulatory component of the immune system. The signals that maintain Treg stability and potentiate their function remain obscure. Here we show that the immune cell surface ligand semaphorin-4a (Sema4a) Sema treated and NRP1 knock outs were compared to untreated wild type T cell controls

ORGANISM(S): Mus musculus

SUBMITTER: David Finkelstein

PROVIDER: E-GEOD-41185 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Stability and function of regulatory T cells is maintained by a neuropilin-1-semaphorin-4a axis.

Delgoffe Greg M GM Woo Seng-Ryong SR Turnis Meghan E ME Gravano David M DM Guy Cliff C Overacre Abigail E AE Bettini Matthew L ML Vogel Peter P Finkelstein David D Bonnevier Jody J Workman Creg J CJ Vignali Dario A A DA

Nature 20130804 7466

Regulatory T cells (Treg cells) have a crucial role in the immune system by preventing autoimmunity, limiting immunopathology, and maintaining immune homeostasis. However, they also represent a major barrier to effective anti-tumour immunity and sterilizing immunity to chronic viral infections. The transcription factor Foxp3 has a major role in the development and programming of Treg cells. The relative stability of Treg cells at inflammatory disease sites has been a highly contentious subject. ...[more]

PMID: 23913274

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