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Transcription profiling of Rattus norvegicus hypothalamoneurohypophyseal system from euhydrated and dehydrated animals

ABSTRACT: This SuperSeries is composed of the following subset Series:; GSE3110: Comprehensive description of the transcriptome of hypothalamo-neurohypophyseal system in euhydrated and dehydrated rat; GSE3111: Comprehensive description of the transcriptome of PVN in euhydrated and dehydrated rat; GSE3125: Comprehensive description of the transcriptome of neurointermediate lobe in euhydrated and dehydrated rat Experiment Overall Design: Refer to individual Series

ORGANISM(S): Rattus norvegicus

SUBMITTER: David Murphy

PROVIDER: E-GEOD-4130 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A comprehensive description of the transcriptome of the hypothalamoneurohypophyseal system in euhydrated and dehydrated rats.

Hindmarch Charles C Yao Song S Beighton Gemma G Paton Julian J Murphy David D

Proceedings of the National Academy of Sciences of the United States of America 20060123 5

The hypothalamoneurohypophyseal system (HNS) consists of the large peptidergic magnocellular neurons of the supraoptic hypo thalamic nucleus (SON) and the paraventricular hypothalamic nucleus (PVN), the axons of which course through the internal zone of the median eminence and terminate at blood capillaries of the posterior lobe of the pituitary gland. The HNS is a specialized brain neurosecretory apparatus responsible for the production of the antidiuretic peptide hormone vasopressin (VP). VP m ...[more]

PMID: 16432224

Similar Datasets

Comprehensive description of the transcriptome of neurointermediate lobe in euhydrated and dehydrated rat

Project description:The hypothalamic paraventricular (PVN) and supraoptic (SON) nuclei are important integrative structures that regulate co-ordinated responses to perturbations in cardiovascular homeostasis. Through descending projections from parvocellular neurons to the brainstem, the PVN acts as an autonomic 'premotor nucleus', regulating reflex changes in sympathetic nerve activity that are involved in blood pressure and blood volume regulation. Endocrine responses are mediated through axonal projections from SON and PVN magnocellular neurons (MCNs) to the capillaries of the posterior pituitary neural lobe. In response to dehydration, a massive release of the antidiuretic peptide hormone vasopressin (VP) into the circulation is accompanied by a dramatic functional remodelling of the HNS. We have used microarrays to comprehensively catalogue the genes expressed in the PVN, the SON and the neurointermediate lobe (NIL) of the pituitary gland. Further, we have identified transcripts that are regulated as a consequence of dehydration, as well as RNAs that are enriched in either the PVN or the SON. We suggest that these differentially expressed genes represent candidate regulators and effectors of HNS activity and remodelling. Keywords: DEHYDRATED - NIL

2005-12-01 | GSE3125 | GEO

Transcription profiling of rat neurointermediate lobe in euhydrated and dehydrated animals

2008-06-12 | E-GEOD-3125 | biostudies-arrayexpress

Transcription profiling of rat hypothalamo-neurohypophyseal system in euhydrated and dehydrated animals

2008-06-12 | E-GEOD-3110 | biostudies-arrayexpress

Transcription profiling of rat hypothalamic paraventricular (PVN)nuclei in euhydrated and dehydrated animals

2008-06-12 | E-GEOD-3111 | biostudies-arrayexpress

Comprehensive description of the transcriptome of PVN in euhydrated and dehydrated rat

2005-12-01 | GSE3111 | GEO

Comprehensive description of the transcriptome of hypothalamo-neurohypophyseal system in euhydrated and dehydrated rat

2005-12-01 | GSE3110 | GEO

Transcription profiling of rat supraoptic nucleus in euhydrated and dehydrated rats.

Project description:The hypothalamo-neurohypophyseal system (HNS) is crucial for osmoregulation. The HNS consists of the magnocellular neurons (MCNs) of the hypothalamus that have their axons terminating in the posterior pituitary. The HNS exerts its role in water balance via the release of the anti-diuretic hormone vasopressin (VP). Following dehydration VP is released into the general circulation. By binding to V2-type receptors located in the kidney, VP decrease the amount of water lost in urine. An osmotic stimulus also elicits an increase in VP gene expression and a functional remodelling of the entire HNS. We want to understand this plasticity in terms of the co-ordinated reprogramming of gene expression. We thus used Affymetrix U34a rat GeneChips to examine the dynamics of gene expression plasticity over the duration of a dehydration stimulus. Arrays were probed in triplicate with targets derived from SON of control rats, and rats dehydrated for 1 and for 3 days. Transcripts were thus identified that respond early to dehydration (up- or down-regulated after only 1day of dehydration), or that respond late (up- or down-regulated at 3 days of dehydration).Â Experiment Overall Design: 3 chips hybridised with control SON were compared to 3 chips hybridised with 1 day dehydrated SON and 3 chips hybridised with 3 day dehydrated SON

2007-11-06 | E-GEOD-3131 | biostudies-arrayexpress

Rattus norvegicus

Project description:Comprehensive description of the transcriptome of PVN in euhydrated and dehydrated rat

| PRJNA104791 | ENA

Rattus norvegicus

Project description:Comprehensive description of the transcriptome of neurointermediate lobe in euhydrated and dehydrated rat

| PRJNA104779 | ENA

The Transcriptome of the rat hypothalamo-neurohypophyseal system is highly strain-dependant

Project description:We have used microarrays to comprehensively describe the transcriptomes of the supraoptic nucleus (SON), the paraventricular nucleus (PVN) and the neurointermediate lobe (NIL) of adult male Sprague-Dawley (SD) and Wistar-Kyoto (WKY) rats, as well as the paraventricular nucleus of Wistar (WIST) rats. Comparison of these gene lists has enabled us to identify surprisingly large differences in hypothalamo-neurohypophyseal system gene expression patterns in these three strains. We have also shown that different transcript populations are enriched in the PVN and the SON of SD and WKY rats. The transcriptome differences catalogued here may be molecular substrates for the neuro-humoral phenotypic differences exhibited by different strains of rats. Keywords: Transcriptome, Hypothalamo-neurohypophyseal system, Genetic

2008-09-22 | GSE8491 | GEO

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