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Gene expression data in mouse fetal lungs

ABSTRACT: Microarray data of mouse postnatal lungs between day 1 and 6 weeks of age. The results provide a general insight into the gene expression profile during the alveolar phase of lung development. We obtained lung tissue of healthy postnatal mice, 4-5 replicates at each time point. Time points were day1, day4, day7, day14, and day 42.

ORGANISM(S): Mus musculus

SUBMITTER: Kusum Pandit 

PROVIDER: E-GEOD-41412 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Reconstructing dynamic microRNA-regulated interaction networks.

Schulz Marcel H MH   Pandit Kusum V KV   Lino Cardenas Christian L CL   Ambalavanan Namasivayam N   Kaminski Naftali N   Bar-Joseph Ziv Z  

Proceedings of the National Academy of Sciences of the United States of America 20130828 39

The regulation of gene expression in cells, including by microRNAs (miRNAs), is a dynamic process. Current methods for identifying miRNA targets by combining sequence and miRNA and mRNA expression data do not adequately use the temporal information and thus miss important miRNAs and their targets. We developed the MIRna Dynamic Regulatory Events Miner (mirDREM), a probabilistic modeling method that uses input-output hidden Markov models to reconstruct dynamic regulatory networks that explain how  ...[more]

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