Bovine granulosa cell response to FGF18
Ontology highlight
ABSTRACT:
ORGANISM(S): Bos taurus
SUBMITTER: Christopher Price
PROVIDER: E-GEOD-41480 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Divergence of intracellular signaling pathways and early response genes of two closely related fibroblast growth factors, FGF8 and FGF18, in bovine ovarian granulosa cells.
Jiang Zhongliang Z Guerrero-Netro Hilda M HM Juengel Jennifer L JL Price Christopher A CA
Molecular and cellular endocrinology 20130523 1-2
Fibroblast growth factors (FGFs) modulate ovarian function, including FGF8 and FGF18. These FGFs activate the same receptors, although FGF18 is unusual in that it increases apoptosis in ovarian granulosa cells whereas the 'typical' response to FGF is increased proliferation. The objective of the present study was to determine which early response genes and pathways are activated by FGF8 and FGF18 in bovine granulosa cells. FGF8 increased abundance of mRNA encoding the FGF-responsive genes SPRY1, ...[more]
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