Development of Helicobacter pylori microarrays to test pathogenicity of clinical isolates

ABSTRACT: To distinguish between Helicobacter pylori isolates that may cause greater disease in patients, we used whole genome expression profiling as a platform to study host-pathogen interactions and identify gene signatures associated with isolates from patients with higher cancer risk. Expression profiles were studied for 3 clinical isolates from a region of high gastric cancer incidence (PZ5056, PZ5080, PZ5086) in Colombia and 3 isolates from a region with low gastric cancer incidence in Colombia (PZ5004, PZ5024, PZ5026). Each experiment was done in triplicate by infecting monolayers of gastric epithelial cells for 1 hour with the isolates.

ORGANISM(S): Homo sapiens

SUBMITTER: Alexander Sheh 

PROVIDER: E-GEOD-41497 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress