Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Leen Jamal
PROVIDER: E-GEOD-41527 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Nature cell biology 20140323 4
Basal-like breast carcinoma is characterized by poor prognosis and high intratumour heterogeneity. In an immortalized basal-like breast epithelial cell line, we identified two anticorrelated gene-expression programs that arise among single extracellular matrix (ECM)-attached cells during organotypic three-dimensional culture. The first contains multiple TGF-β-related genes including TGFBR3, whereas the second contains JUND and the basal-like marker KRT5. TGFBR3 and JUND interconnect through four ...[more]