Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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Role of platelet micrornas in sickle cell disease


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Shilpa Jain 

PROVIDER: E-GEOD-41575 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


<h4>Background</h4>Increased platelet activation in sickle cell disease (SCD) contributes to a state of hypercoagulability and confers a risk of thromboembolic complications. The role for post-transcriptional regulation of the platelet transcriptome by microRNAs (miRNAs) in SCD has not been previously explored. This is the first study to determine whether platelets from SCD exhibit an altered miRNA expression profile.<h4>Methods and findings</h4>We analyzed the expression of miRNAs isolated from  ...[more]

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