Ontology highlight
ABSTRACT:
ORGANISM(S): Rattus norvegicus
SUBMITTER: Ruth Yu
PROVIDER: E-GEOD-41579 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Ding Ning N Yu Ruth T RT Subramaniam Nanthakumar N Sherman Mara H MH Wilson Caroline C Rao Renuka R Leblanc Mathias M Coulter Sally S He Mingxiao M Scott Christopher C Lau Sue L SL Atkins Annette R AR Barish Grant D GD Gunton Jenny E JE Liddle Christopher C Downes Michael M Evans Ronald M RM
Cell 20130401 3
Liver fibrosis is a reversible wound-healing response involving TGFβ1/SMAD activation of hepatic stellate cells (HSCs). It results from excessive deposition of extracellular matrix components and can lead to impairment of liver function. Here, we show that vitamin D receptor (VDR) ligands inhibit HSC activation by TGFβ1 and abrogate liver fibrosis, whereas Vdr knockout mice spontaneously develop hepatic fibrosis. Mechanistically, we show that TGFβ1 signaling causes a redistribution of genome-wid ...[more]