Deletion effect of HstD in gene expression
Ontology highlight
ABSTRACT:
ORGANISM(S): Aspergillus oryzae
SUBMITTER: Kazuhiro Iwashita
PROVIDER: E-GEOD-41612 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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Project description:In eukaryotic cells , histone deactylase plays key roles in the diverse process such as genomic stabillity, differenciation, and metabolism. These enzymes also conserved in filamentous fungi, and their functios has been started to understand some fungal biological process such as development, stress responce, and secondary metabolism. We found deletion of HstD homolog of yeast Hst4, affected development, secondary metabolism in aspergillyus oryzae. To acess the global effect of gene expression by HstD deletion, we performed microarray analysis, and results showed metabolite related gene was mainly alterd in DHstD. This result sugested the HstD will concerned golobal regulation of secondary metabolism in filmatous fungi.
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