Differential expression in Wn5a and vector transduced 4T1 cells.
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Rosa Serra
PROVIDER: E-GEOD-41793 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
WNT5A inhibits metastasis and alters splicing of Cd44 in breast cancer cells.
Jiang Wen W Crossman David K DK Mitchell Elizabeth H EH Sohn Philip P Crowley Michael R MR Serra Rosa R
PloS one 20130306 3
Wnt5a is a non-canonical signaling Wnt. Low expression of WNT5A is correlated with poor prognosis in breast cancer patients. The highly invasive breast cancer cell lines, MDA-MB-231 and 4T1, express very low levels of WNT5A. To determine if enhanced expression of WNT5A would affect metastatic behavior, we generated WNT5A expressing cells from the 4T1 and MDA-MB-231 parental cell lines. WNT5A expressing cells demonstrated cobblestone morphology and reduced in vitro migration relative to controls. ...[more]
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