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Transcription profiling of whole testis from wild type, bgcn- and Os+bgcn- Drosophila

ABSTRACT: Whole testes were dissected from adult males. RNA from five or six biological replicates were generated and the expression profiles were determined using Affymetrix Drosophila Genechip 1 arrays. Comparisons between the bgcn- and Os+bgcn- groups allowed for the identification of stem cell genes.

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Natalie Terry

PROVIDER: E-GEOD-4188 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Novel regulators revealed by profiling Drosophila testis stem cells within their niche.

Terry Natalie A NA Tulina Natalia N Matunis Erika E DiNardo Stephen S

Developmental biology 20060417 1

Stem cells are defined by the fact that they both self-renew, producing additional stem cells, and generate lineal descendants that differentiate into distinct functional cell types. In Drosophila, a small germline stem cell population is influenced by a complex microenvironment, the stem cell niche, which itself includes a somatic stem cell population. While stem cells are unique, their immediate descendants retain considerable stem cell character as they mitotically amplify prior to differenti ...[more]

PMID: 16616121

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