Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Peripheral blood mononuclear cell gene expression in chronic obstructive pulmonary disease

ABSTRACT: Expression data were generated on 136 subjects from the COPDGene® study using Affymetrix microarrays. Multiple linear regression with adjustment for covariates (gender, age, body mass index, family history, smoking status, pack years) was used to identify candidate genes and Ingenuity Pathway Analysis was used to identify candidate pathways. Candidate genes identified included those that play a role in the immune system, inflammatory responses, and sphingolipid metabolism. Many of our final candidate genes also show an association with related disease phenotypes such as emphysema, gas trapping, and 6-minute walk distance. 42 control subjects and 94 subjects with varying severity of COPD had PBMC gene expression profiles generated. All subjects are non-hispanic white, current or former smokers.

ORGANISM(S): Homo sapiens

SUBMITTER: Grant Hughes 

PROVIDER: E-GEOD-42057 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

Peripheral blood mononuclear cell gene expression in chronic obstructive pulmonary disease.

Bahr Timothy M TM   Hughes Grant J GJ   Armstrong Michael M   Reisdorph Rick R   Coldren Christopher D CD   Edwards Michael G MG   Schnell Christina C   Kedl Ross R   LaFlamme Daniel J DJ   Reisdorph Nichole N   Kechris Katerina J KJ   Bowler Russell P RP  

American journal of respiratory cell and molecular biology 20130801 2

Although most cases of chronic obstructive pulmonary disease (COPD) occur in smokers, only a fraction of smokers develop the disease. We hypothesized distinct molecular signatures for COPD and emphysema in the peripheral blood mononuclear cells (PBMCs) of current and former smokers. To test this hypothesis, we identified and validated PBMC gene expression profiles in smokers with and without COPD. We generated expression data on 136 subjects from the COPDGene study, using Affymetrix U133 2.0 mic  ...[more]

Similar Datasets

Transcriptomics Dendritic cells are contained within melanocytic nevus nests in vivo and can alter gene expression of epidermal melanocytes in vitro
2014-12-15 | E-GEOD-61353 | biostudies-arrayexpress
Transcriptomics Gene expression regulation by angiotensin II in late gestation fetal sheep
2013-08-09 | E-GEOD-45463 | biostudies-arrayexpress
Proteomics Multiomics Characterization of Potential Therapeutic Vulnerabilities in Low-grade Serous Ovarian Carcinoma
2021-05-17 | PXD019544 | Pride
Transcriptomics Peripheral blood mononuclear cell gene expression in chronic obstructive pulmonary disease
2013-05-06 | GSE42057 | GEO
Transcriptomics Gene expression patterns in house dust mite stimulated CD4 T cells and IgG:IgE ratios
2015-11-03 | E-GEOD-70760 | biostudies-arrayexpress
Transcriptomics DNA methylation anaylsis of placenta samples exposed to variable levels of arsenic during pregnancy
2016-07-01 | E-GEOD-71678 | biostudies-arrayexpress
Transcriptomics Human Immune Response Dynamics - gene expression
2015-11-01 | E-MTAB-2313 | biostudies-arrayexpress
Transcriptomics Gene expression patterns in allergen-driven CD4 T cell responses from human atopics with or without asthma.
2016-02-25 | E-GEOD-73482 | biostudies-arrayexpress
Transcriptomics Transcriptome of non-involved lung parenchyma from smoker lung adenocarcinoma patients from Milan, Italy.
2016-01-20 | E-GEOD-71181 | biostudies-arrayexpress
Transcriptomics Novel Regions of Variable DNA Methylation in Human Placenta associated with Newborn Neurobehavioral Traits
2016-06-01 | E-GEOD-75248 | biostudies-arrayexpress