Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Yu Liu
PROVIDER: E-GEOD-42100 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Golipour Azadeh A David Laurent L Liu Yu Y Jayakumaran Gowtham G Hirsch Calley L CL Trcka Dan D Wrana Jeffrey L JL
Cell stem cell 20121201 6
Reprogramming of somatic cells to a pluripotent state via expression of Oct4, Klf4, Myc, and Sox2 is a multistep process involving phased changes in gene expression. Here, we focus on the later stages of reprogramming, termed maturation and stabilization. We show that the stabilization phase and the acquisition of pluripotency are dependent on the removal of transgene expression late in the maturation phase. Clonal analysis of cells undergoing reprogramming revealed subsets of stabilization-comp ...[more]