Unknown,Transcriptomics,Genomics,Proteomics

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Expression changes between C. albicans white and opaque cell types and mutant strains

ABSTRACT: The goal of this study is to characterize the transcriptional regulatory network that controls white-opaque cell-type switching in Candida albicans. This dataset includes microarrays comparing expression levels in wild-type white and opaque cell types, as well as 6 different transcription factor deletion strains. All samples were hybridized against a common mixed reference to allow for comparison between any two datasets within this study. Gene expression arrays were performed on wild-type and transcription factor deletion white and opaque a/a cell types . High and low intensity scans were performed. Background and saturated spots were filtered out, as indicated by null. Data from each scan was normalized by lowess normalization to enable transformation across any pair of datasets. All data presented are log2 ratios of Cy5/Cy3 Each sample was hybridized against a mixed reference sample to allow for transformation between any of the individual samples (white vs. opaque, wild-type vs. mutant)

ORGANISM(S): Candida albicans

SUBMITTER: Aaron Hernday 

PROVIDER: E-GEOD-42134 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Identification and characterization of a previously undescribed family of sequence-specific DNA-binding domains.

Lohse Matthew B MB   Hernday Aaron D AD   Fordyce Polly M PM   Noiman Liron L   Sorrells Trevor R TR   Hanson-Smith Victor V   Nobile Clarissa J CJ   DeRisi Joseph L JL   Johnson Alexander D AD  

Proceedings of the National Academy of Sciences of the United States of America 20130422 19

Sequence-specific DNA-binding proteins are among the most important classes of gene regulatory proteins, controlling changes in transcription that underlie many aspects of biology. In this work, we identify a transcriptional regulator from the human fungal pathogen Candida albicans that binds DNA specifically but has no detectable homology with any previously described DNA- or RNA-binding protein. This protein, named White-Opaque Regulator 3 (Wor3), regulates white-opaque switching, the ability  ...[more]

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