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Murine bone marrow gene expression profiling

ABSTRACT: Mice have been treated with olaptesed pegol (NOX-A12). Whole BM cells have been harvested, RNA isolated, and gene expression profiling was performed on cDNA using Mouse Genome 430 2.0 array. Untreated mice have been used as control. Mice have been treated with NOX-A12. Whole BM cells have been harvested, RNA isolated, and gene expression profiling was performed on cDNA using Mouse Genome 430 2.0 array. Untreated mice have been used as control.

ORGANISM(S): Mus musculus

SUBMITTER: Aldo Roccaro 

PROVIDER: E-GEOD-42257 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Bone marrow (BM) metastasis remains one of the main causes of death associated with solid tumors as well as multiple myeloma (MM). Targeting the BM niche to prevent or modulate metastasis has not been successful to date. Here, we show that stromal cell-derived factor-1 (SDF-1/CXCL12) is highly expressed in active MM, as well as in BM sites of tumor metastasis and report on the discovery of the high-affinity anti-SDF-1 PEGylated mirror-image l-oligonucleotide (olaptesed-pegol). In vivo confocal i  ...[more]

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