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Transcription profiling of liver from mice deficient for IFNg or both IFNg and Suppressor of Cytokine Signalling-1 at 0.5 to 48 hours after INFg treatment

ABSTRACT: Timecourse analysis of Interferon-Gamma (IFNg) signalling in mice deficient for IFNg or both IFNg and Suppressor of Cytokine Signalling-1 (SOCS1).

ORGANISM(S): Mus musculus

SUBMITTER: Sam Wormald

PROVIDER: E-GEOD-4232 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The comparative roles of suppressor of cytokine signaling-1 and -3 in the inhibition and desensitization of cytokine signaling.

Wormald Samuel S Zhang Jian-Guo JG Krebs Danielle L DL Mielke Lisa A LA Silver Jeremy J Alexander Warren S WS Speed Terence P TP Nicola Nicos A NA Hilton Douglas J DJ

The Journal of biological chemistry 20060210 16

Negative feedback is a mechanism commonly employed in biological processes as a means of maintaining homeostasis. We have investigated the roles of suppressor of cytokine signaling (SOCS) proteins in regulating the kinetics of negative feedback in response to cytokine signaling. In mouse livers and bone marrow-derived macrophages, both interferon-gamma (IFNgamma) and interleukin-6 (IL-6) rapidly induced the tyrosine phosphorylation of signal transducer and activator of transcription-1 (STAT1) an ...[more]

PMID: 16473883

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Mus musculus

Project description:Interferon-gamma timecourse in IFNg-/- and SOCS1-/-IFNg-/- mouse livers

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Expression data from CD71+ cells from the bone marrow of WT, CD70TG, IFNg-/- and CD70TG*IFNg-/- mice.

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