Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Daisuke Okuzaki
PROVIDER: E-GEOD-42327 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Katahira Jun J Okuzaki Daisuke D Inoue Hitomi H Yoneda Yoshihiro Y Maehara Kazumitsu K Ohkawa Yasuyuki Y
Nucleic acids research 20130517 14
The transcription-export complex (TREX) couples mRNA transcription, processing and nuclear export. We found that CFIm68, a large subunit of a heterotetrameric protein complex mammalian cleavage factor I (CFIm), which is implicated in alternative polyadenylation site choice, co-purified with Thoc5, a component of human TREX. Immunoprecipitation using antibodies against different components of TREX indicated that most likely both complexes interact via an interaction between Thoc5 and CFIm68. Micr ...[more]