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Transcription profiling of mouse adrenal gland from circadian clock deficien PerCry1 double mutant after 46 or 54h in DD

ABSTRACT: This array set was used to determine clock regulated genes in the adrenal gland that are not necessarily rhythmic but still controlled by the circadian TTL. Experiment Overall Design: LD entrained animals were released into DD and whole adrenal glands were dissected at the 46/54 h specified time points after lights off.

ORGANISM(S): Mus musculus

SUBMITTER: Henrik Oster

PROVIDER: E-GEOD-4239 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The circadian rhythm of glucocorticoids is regulated by a gating mechanism residing in the adrenal cortical clock.

Oster Henrik H Damerow Sebastian S Kiessling Silke S Jakubcakova Vladimira V Abraham Diya D Tian Jiong J Hoffmann Matthias W MW Eichele Gregor G

Cell metabolism 20060801 2

In mammals, the master clock of the suprachiasmatic nuclei (SCN) and subordinate clocks found throughout the body coordinate circadian rhythms of behavior and physiology. We characterize the clock of the adrenal, an important endocrine gland that synchronizes physiological and metabolic rhythms. Clock gene expression was detected in the outer adrenal cortex prefiguring a role of the clock in regulating gluco- and mineral corticoid biogenesis. In Per2/Cry1 double mutant mice, which lack a circadi ...[more]

PMID: 16890544

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