Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Gene expression profiling of glioblastoma cell lines transfected with FGFR3-TACC3

ABSTRACT: Gene expression profiling of SNB19 and U251 glioblastoma cell lines transfected with the FGFR3-TACC3 fusion, FGFR3 wildtype and TACC3 wildtype constructs. SNB19 and U251 cells were transfected with different clones of the FGFR3-TACC3 fusion and with wildtype FGFR3 and TACC3 constructs. Total RNA was extracted and hybridized onto Agilent dual channel gene expression microarrays. In each hybridization, empty vector transfected SNB19 or U251 cells were hybridized into the reference channel.

ORGANISM(S): Homo sapiens

SUBMITTER: Matti Annala 

PROVIDER: E-GEOD-42401 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

Fusion genes are chromosomal aberrations that are found in many cancers and can be used as prognostic markers and drug targets in clinical practice. Fusions can lead to production of oncogenic fusion proteins or to enhanced expression of oncogenes. Several recent studies have reported that some fusion genes can escape microRNA regulation via 3'-untranslated region (3'-UTR) deletion. We performed whole transcriptome sequencing to identify fusion genes in glioma and discovered FGFR3-TACC3 fusions  ...[more]

Similar Datasets

Transcriptomics Gene expression profiling of glioblastoma cell lines transfected with FGFR3-TACC3
2012-12-01 | GSE42401 | GEO
Methylation profiling DNA methylation analysis of glioblastomas harboring FGFR3-TACC3 fusions identifies a methylation subclass with better patient survival.
2022-05-16 | GSE200647 | GEO
Transcriptomics Microarray of Human astrocytes transduced with lentivirus expressing FGFR3-TACC3 treated with vehicle, FGFR3-TACC3 treated with the FGFR inhibitor PD173074 for 12h, FGFR3-TACC3-K508M treated with vehicle or empty vector treated with vehicle
2017-10-17 | E-MTAB-6037 | biostudies-arrayexpress
Transcriptomics Gene expression data from RT112 following FGFR3 knock-down using FGFR3 siRNAs
2018-02-16 | GSE84732 | GEO
Transcriptomics High resolution aCGH of the FGFR3-TACC3 locus in glioblastoma patients
2012-12-01 | E-GEOD-42400 | biostudies-arrayexpress
Genomics,Multiomics
| PRJNA181293 | ENA
Transcriptomics An in vitro study of the development of resistance to FGFR inhibition in two urothelial carcinoma cell lines
2022-11-09 | GSE201395 | GEO
Genomics,Multiomics Homo sapiens
| PRJNA181295 | ENA
Transcriptomics Chromatin decondensation is sufficient to alter nuclear organization in embryonic stem cells
2014-12-01 | GSE62379 | GEO
Transcriptomics Gene expressing profiling of PC12 cells expressing the FGFR3 mutation responsible for thanatophoric dysplasia type II
2005-05-06 | GSE2606 | GEO