Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Rui Lu
PROVIDER: E-GEOD-42463 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Cai Ling L Rothbart Scott B SB Lu Rui R Xu Bowen B Chen Wei-Yi WY Tripathy Ashutosh A Rockowitz Shira S Zheng Deyou D Patel Dinshaw J DJ Allis C David CD Strahl Brian D BD Song Jikui J Wang Gang Greg GG
Molecular cell 20121227 3
Polycomb repressive complex 2 (PRC2) regulates pluripotency, differentiation, and tumorigenesis through catalysis of histone H3 lysine 27 trimethylation (H3K27me3) on chromatin. However, the mechanisms that underlie PRC2 recruitment and spreading on chromatin remain unclear. Here we report that histone H3 lysine 36 trimethylation (H3K36me3) binding activity is harbored in the Tudor motifs of PRC2-associated polycomb-like (PCL) proteins PHF1/PCL1 and PHF19/PCL3. Ectopically expressed PHF1 induced ...[more]