Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Genome wide profiling of FOXE1 binding sites in PCCL3 rat cells

ABSTRACT: FoxE1 transcriptional profiling of rat PCCL3 cells comparing wild type cells with FoxE1 silenced cells and scramble treated with FoxE1 silenced cells. Three-condition experiment, FoxE1 silenced vs. Wild type cells. Biological replicates: 4 replicates, 1pooled sample dye-swap. and FoxE1 silenced vs scramble treated cells. Biological replicates: 4 replicates, 1 pooled sample dye-swap.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Pilar Santisteban

PROVIDER: E-GEOD-42497 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

New insights into FoxE1 functions: identification of direct FoxE1 targets in thyroid cells.

Fernández Lara P LP López-Márquez Arístides A Martínez Angel M AM Gómez-López Gonzalo G Santisteban Pilar P

PloS one 20130513 5

<h4>Background</h4>FoxE1 is a thyroid-specific forkhead transcription factor essential for thyroid gland development, as well as for the maintenance of the thyroid differentiated state in adults. FoxE1 recognizes and binds to a short DNA sequence present in thyroglobulin (Tg) and thyroperoxidase (Tpo) promoters, but FoxE1 binding to regulatory regions other than Tg and Tpo promoters remains almost unexplored. Improving knowledge of the regulatory functions of FoxE1 is necessary to clarify its ro ...[more]

PMID: 23675434

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Dataset Information

Genome wide profiling of FOXE1 binding sites in PCCL3 rat cells

Publications

New insights into FoxE1 functions: identification of direct FoxE1 targets in thyroid cells.

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