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Unknown,Transcriptomics,Genomics,Proteomics

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The Hematopoietic System - Myeloid arm

ABSTRACT: We used microarray to create a normal cell landscape for the myeloid arm of the hematopoietic system. Mononuclear bone marrow cells from heathly donors were enriched for 34+ and hematopoietic stem and progenitor cells were sorted by FACS.

ORGANISM(S): Homo sapiens

SUBMITTER: Nicolas Rapin

PROVIDER: E-GEOD-42519 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Comparing cancer vs normal gene expression profiles identifies new disease entities and common transcriptional programs in AML patients.

Rapin Nicolas N Bagger Frederik Otzen FO Jendholm Johan J Mora-Jensen Helena H Krogh Anders A Kohlmann Alexander A Thiede Christian C Borregaard Niels N Bullinger Lars L Winther Ole O Theilgaard-Mönch Kim K Porse Bo T BT

Blood 20131220 6

Gene expression profiling has been used extensively to characterize cancer, identify novel subtypes, and improve patient stratification. However, it has largely failed to identify transcriptional programs that differ between cancer and corresponding normal cells and has not been efficient in identifying expression changes fundamental to disease etiology. Here we present a method that facilitates the comparison of any cancer sample to its nearest normal cellular counterpart, using acute myeloid l ...[more]

PMID: 24363398

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ERG promotes the maintenance of hematopoietic stem cells by restricting their differentiation

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2015-09-21 | E-GEOD-69873 | biostudies-arrayexpress

Pre-leukemic Cebpa mutant myeloid progenitors

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2014-02-05 | E-GEOD-49975 | biostudies-arrayexpress

Development of MLL-rearranged leukemia is dependent on a transcriptional program orchestradt by C/EBPα

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Deletion of Cebpa from HSCs

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2013-12-10 | E-GEOD-42498 | biostudies-arrayexpress

In Vitro Transformation of Primary Human CD34+ Cells by AML Fusion Oncogenes: Early Gene Expression Profiling Reveals Possible Drug Target in AML

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