Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Esperanza MartÃn-Sánchez
PROVIDER: E-GEOD-42595 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
PloS one 20141111 11
Currently, there is no efficient therapy for patients with peripheral T cell lymphoma (PTCL). The Proviral Integration site of Moloney murine leukemia virus (PIM) kinases are important mediators of cell survival. We aimed to determine the therapeutic value of PIM kinases because they are overexpressed in PTCL patients, T cell lines and primary tumoral T cells. PIM kinases were inhibited genetically (using small interfering and short hairpin RNAs) and pharmacologically (mainly with the pan-PIM in ...[more]