Patient specific orthotopic glioblastoma xenograft models recapitulate the histopathology and biology of human glioblastomas in situ
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ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Jinkuk Kim
PROVIDER: E-GEOD-42670 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Patient-specific orthotopic glioblastoma xenograft models recapitulate the histopathology and biology of human glioblastomas in situ.
Joo Kyeung Min KM Kim Jinkuk J Jin Juyoun J Kim Misuk M Seol Ho Jun HJ Muradov Johongir J Yang Heekyoung H Choi Yoon-La YL Park Woong-Yang WY Kong Doo-Sik DS Lee Jung-Il JI Ko Young-Hyeh YH Woo Hyun Goo HG Lee Jeongwu J Kim Sunghoon S Nam Do-Hyun DH
Cell reports 20130117 1
Frequent discrepancies between preclinical and clinical results of anticancer agents demand a reliable translational platform that can precisely recapitulate the biology of human cancers. Another critical unmet need is the ability to predict therapeutic responses for individual patients. Toward this goal, we have established a library of orthotopic glioblastoma (GBM) xenograft models using surgical samples of GBM patients. These patient-specific GBM xenograft tumors recapitulate histopathologica ...[more]
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