Profiling Genome-wide Chromatin Methylation with Engineered Posttranslation Apparatus within Living Cells
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Rui Wang
PROVIDER: E-GEOD-42792 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Profiling genome-wide chromatin methylation with engineered posttranslation apparatus within living cells.
Wang Rui R Islam Kabirul K Liu Ying Y Zheng Weihong W Tang Haiping H Lailler Nathalie N Blum Gil G Deng Haiteng H Luo Minkui M
Journal of the American Chemical Society 20130110 3
Protein methyltransferases (PMTs) have emerged as important epigenetic regulators in myriad biological processes in both normal physiology and disease conditions. However, elucidating PMT-regulated epigenetic processes has been hampered by ambiguous knowledge about in vivo activities of individual PMTs particularly because of their overlapping but nonredundant functions. To address limitations of conventional approaches in mapping chromatin modification of specific PMTs, we have engineered the c ...[more]
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