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Genome-wide pairwise analysis of normal and spontaneously transformed adipose tissue derived hMSCs

ABSTRACT: hMSCs are perspective source for applications in the field of regeneraitve medicine. Biosafety of cultivated in vitro multipotent cells prior transplantation is one of the important issues. Genome-wide pairwise expression analysis of normal and immortalized hMSCs was performed to determine aspects of spontaneous transformation and immortalization mechanisms during cultivation of hMSCs. Data has provided insight into functionally connected genes involved in spontaneous transformation of hMSCs in vitro. Multipotent stromal cells (MSCs) were isolated from adipose tissue samples obtained from 6 healthy donors. Total RNA was isolated from 6 normal and 6 donor-matched spontaneously transformed hMSC cultures in vitro for pair-wise global comparison.

ORGANISM(S): Homo sapiens

SUBMITTER: Denis Omelchenko

PROVIDER: E-GEOD-42809 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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