Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
DISEASE(S): integrated HPV16 only
SUBMITTER: Mark Robert Pett
PROVIDER: E-GEOD-4289 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Pett Mark R MR Herdman M Trent MT Palmer Roger D RD Yeo Giles S H GS Shivji Mahmud K MK Stanley Margaret A MA Coleman Nicholas N
Proceedings of the National Academy of Sciences of the United States of America 20060227 10
Integration of high-risk human papillomavirus (HRHPV) into the host genome is a key event in cervical neoplastic progression. Integration is associated with deregulated expression of the viral oncogenes E6 and E7 and acquisition of a selective growth advantage for cells containing integrants. Overexpression of the viral transcriptional regulator E2 from heterologous promoters has an inhibitory effect on transcription from integrated HRHPV. Therefore, we hypothesized that loss of E2-expressing ep ...[more]