Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human cervical keratinocytes infected with HPV16


ABSTRACT: Integration of high-risk human papillomavirus (HRHPV) into the host genome is a key event in cervical neoplastic progression. Integration is associated with deregulated expression of the viral oncogenes E6 and E7 and acquisition of a selective growth advantage.

ORGANISM(S): Homo sapiens

DISEASE(S): integrated HPV16 only

SUBMITTER: Mark Robert Pett 

PROVIDER: E-GEOD-4289 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Selection of cervical keratinocytes containing integrated HPV16 associates with episome loss and an endogenous antiviral response.

Pett Mark R MR   Herdman M Trent MT   Palmer Roger D RD   Yeo Giles S H GS   Shivji Mahmud K MK   Stanley Margaret A MA   Coleman Nicholas N  

Proceedings of the National Academy of Sciences of the United States of America 20060227 10


Integration of high-risk human papillomavirus (HRHPV) into the host genome is a key event in cervical neoplastic progression. Integration is associated with deregulated expression of the viral oncogenes E6 and E7 and acquisition of a selective growth advantage for cells containing integrants. Overexpression of the viral transcriptional regulator E2 from heterologous promoters has an inhibitory effect on transcription from integrated HRHPV. Therefore, we hypothesized that loss of E2-expressing ep  ...[more]

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