Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Genevieve Almouzni
PROVIDER: E-GEOD-42951 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Lacoste Nicolas N Woolfe Adam A Tachiwana Hiroaki H Garea Ana Villar AV Barth Teresa T Cantaloube Sylvain S Kurumizaka Hitoshi H Imhof Axel A Almouzni Geneviève G
Molecular cell 20140213 4
Centromeres are essential for ensuring proper chromosome segregation in eukaryotes. Their definition relies on the presence of a centromere-specific H3 histone variant CenH3, known as CENP-A in mammals. Its overexpression in aggressive cancers raises questions concerning its effect on chromatin dynamics and contribution to tumorigenesis. We find that CenH3 overexpression in human cells leads to ectopic enrichment at sites of active histone turnover involving a heterotypic tetramer containing Cen ...[more]