Canonical Nlrp3 inflammasome activation links systemic age-related inflammation with functional decline
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ABSTRACT: This experiment was performed to analyze the contribution of NLRP3 inflammasome activation to age-related changes in hippocampal RNA. The hypothesis was that decreased inflammasome activation would reduce hippocampal inflammation. Results indicate that inflammasome knockout animals are protected from age-related changes in hippocampal gene expression Gene expression profiles of young (1 month) and old (21-23 month) wild type, CIAS -/- and ASC -/- mouse hippocampal tissue were compared. Total mRNA was extracted using Trizol.
ORGANISM(S): Mus musculus
SUBMITTER: Ryan Grant
PROVIDER: E-GEOD-43034 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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