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Next Generation Sequencing Facilitates Quantitative Analysis of CNE1-mock, CNE1-BART1, CNE-BART3, CNE1-BART7 cells

ABSTRACT: By using NGS-derived retinal transcriptome profiling (RNA-seq) to compare the gene expression profiling between 4 differently treated NPC cells Examination of different gene expression in EBV-miRNA-BART1/3/7 lentivirus and their control infected nasopharyngeal carcinoma cells.

ORGANISM(S): Homo sapiens

SUBMITTER: Xin Li

PROVIDER: E-GEOD-43126 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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TGFβR2 is a major target of miR-93 in nasopharyngeal carcinoma aggressiveness.

Lyu Xiaoming X Fang Weiyi W Cai Longmei L Zheng Hang H Ye Yanfen Y Zhang Lan L Li Jinbang J Peng Hong H Cho William C S WC Wang Ena E Marincola Francesco M FM Yao Kaitai K Cai Hongbing H Li Jiliang J Li Xin X

Molecular cancer 20140308

<h4>Background</h4>MiR-17-92 cluster and its paralogues have emerged as crucial regulators of many oncogenes and tumor suppressors. Transforming growth factor-β receptor II (TGFβR2), as an important tumor suppressor, is involved in various cancer types. However, it is in cancer that only two miRNAs of this cluster and its paralogues have been reported so far to regulate TGFβR2. MiR-93 is oncogenic, but its targetome in cancer has not been fully defined. The role of miR-93 in nasopharyngeal carci ...[more]

PMID: 24606633

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