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Gene expression profile analysis of normal and type 2 diabetic mouse liver

ABSTRACT: Gene expression profiles in the liver of 9-week-old wild type and diabetic db/db mice were measured by high-throughput sequencing to detect the differentially expressed genes Gene expression profiles of 9-week-old wild type and diabetic db/db mice were generated by high-throughput sequencing using Illumina Genome Analyzer

ORGANISM(S): Mus musculus

SUBMITTER: Qiwei Zhai

PROVIDER: E-GEOD-43314 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gene expression profile analysis of type 2 diabetic mouse liver.

Zhang Fang F Xu Xiang X Zhang Yi Y Zhou Ben B He Zhishui Z Zhai Qiwei Q

PloS one 20130301 3

Liver plays a key role in glucose metabolism and homeostasis, and impaired hepatic glucose metabolism contributes to the development of type 2 diabetes. However, the precise gene expression profile of diabetic liver and its association with diabetes and related diseases are yet to be further elucidated. In this study, we detected the gene expression profile by high-throughput sequencing in 9-week-old normal and type 2 diabetic db/db mouse liver. Totally 12132 genes were detected, and 2627 genes ...[more]

PMID: 23469233

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