Transcriptional profiles of PA1 teratoma cells transfected by RIPK1, RIPK2, RIPK3, or RIPK4
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Jinfeng Liu
PROVIDER: E-GEOD-43362 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Phosphorylation of Dishevelled by protein kinase RIPK4 regulates Wnt signaling.
Huang XiaoDong X McGann James C JC Liu Bob Y BY Hannoush Rami N RN Lill Jennie R JR Pham Victoria V Newton Kim K Kakunda Michael M Liu Jinfeng J Yu Christine C Hymowitz Sarah G SG Hongo Jo-Anne JA Wynshaw-Boris Anthony A Polakis Paul P Harland Richard M RM Dixit Vishva M VM
Science (New York, N.Y.) 20130131 6126
Receptor-interacting protein kinase 4 (RIPK4) is required for epidermal differentiation and is mutated in Bartsocas-Papas syndrome. RIPK4 binds to protein kinase C, but its signaling mechanisms are largely unknown. Ectopic RIPK4, but not catalytically inactive or Bartsocas-Papas RIPK4 mutants, induced accumulation of cytosolic β-catenin and a transcriptional program similar to that caused by Wnt3a. In Xenopus embryos, Ripk4 synergized with coexpressed Xwnt8, whereas Ripk4 morpholinos or catalyti ...[more]
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