Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Christopher Ng
PROVIDER: E-GEOD-43429 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Ng Christopher W CW Yildirim Ferah F Yap Yoon Sing YS Dalin Simona S Matthews Bryan J BJ Velez Patricio J PJ Labadorf Adam A Housman David E DE Fraenkel Ernest E
Proceedings of the National Academy of Sciences of the United States of America 20130122 6
The earliest stages of Huntington disease are marked by changes in gene expression that are caused in an indirect and poorly understood manner by polyglutamine expansions in the huntingtin (HTT) protein. To explore the hypothesis that DNA methylation may be altered in cells expressing mutated HTT, we use reduced representation bisulfite sequencing (RRBS) to map sites of DNA methylation in cells carrying either wild-type or mutant HTT. We find that a large fraction of the genes that change in exp ...[more]