Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Thymidine Kinase and mtDNA Depletion in Human Cardiomyopathy: Epigentic and Translational Evidence for Energy Starvation

ABSTRACT: A comparison of epigenetic nuclear DNA methylation and gene expression changes between human dialated cardiomypathy left ventricle samples and non-failing cardiac left ventricule samples This study addresses how depletion of huaman cardiac left ventricle mitochondrial DNA and epigentic nuclear DNA methylation promote cardiac dysfunction in human dilated cardiomyopathy. Each sample was fluorescently labeled and hybridized to Roche Nimblegen 2.1M Deluxe Promoter Arrays and Expression arrays.

ORGANISM(S): Homo sapiens

SUBMITTER: William Lewis

PROVIDER: E-GEOD-43435 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Thymidine kinase and mtDNA depletion in human cardiomyopathy: epigenetic and translational evidence for energy starvation.

Koczor Christopher A CA Torres Rebecca A RA Fields Earl J EJ Boyd Amy A He Stanley S Patel Nilamkumar N Lee Eva K EK Samarel Allen M AM Lewis William W

Physiological genomics 20130521 14

This study addresses how depletion of human cardiac left ventricle (LV) mitochondrial DNA (mtDNA) and epigenetic nuclear DNA methylation promote cardiac dysfunction in human dilated cardiomyopathy (DCM) through regulation of pyrimidine nucleotide kinases. Samples of DCM LV and right ventricle (n = 18) were obtained fresh at heart transplant surgery. Parallel samples from nonfailing (NF) controls (n = 12) were from donor hearts found unsuitable for clinical use. We analyzed abundance of mtDNA and ...[more]

PMID: 23695887

Publication: 1/2

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Dataset Information

Thymidine Kinase and mtDNA Depletion in Human Cardiomyopathy: Epigentic and Translational Evidence for Energy Starvation

Publications

Thymidine kinase and mtDNA depletion in human cardiomyopathy: epigenetic and translational evidence for energy starvation.

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