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Genomic profiling of primary and metastatic clear cell renal cell carcinoma by array-based comparative genomic hybridization.

ABSTRACT: In this study, we investigated CNAs of 20 primary clear cell renal cell caricinomas (ccRCCs), 20 corresponding metastases and another subsets of 30 primary ccRCCs by 44k oligonucleotide-based array comparative genomic hybridization (array CGH). 20 primary ccRCCs, 20 corresponding metastases and another subsets of 30 primary ccRCCs.

ORGANISM(S): Homo sapiens

SUBMITTER: Takahiro Narimatsu

PROVIDER: E-GEOD-43477 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Downregulation of NDUFB6 due to 9p24.1-p13.3 loss is implicated in metastatic clear cell renal cell carcinoma.

Narimatsu Takahiro T Matsuura Keiko K Nakada Chisato C Tsukamoto Yoshiyuki Y Hijiya Naoki N Kai Tomoki T Inoue Toru T Uchida Tomohisa T Nomura Takeo T Sato Fuminori F Seto Masao M Takeuchi Ichiro I Mimata Hiromitsu H Moriyama Masatsugu M

Cancer medicine 20141015 1

This study was conducted to clarify the genomic profiles of metastatic clear cell renal cell carcinomas (ccRCCs) and identify the genes responsible for development of metastasis. We analyzed the genomic profiles of 20 cases of primary ccRCC and their corresponding metastases using array-based comparative genomic hybridization, and identified 32 chromosomal regions in which gene copy number alterations were detected more frequently in metastases than in the primary tumors. Among these 32 regions, ...[more]

PMID: 25315157

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