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Expression data of mammary epithelial cells during the epithelial-mesenchymal transition

ABSTRACT: The EMT program allows epithelial cells to become endowed with motility, invasiveness and stem cell traits. We investigated difference in signaling networks that are differentially utilized in EMTed and non-EMTed cells, thereby identifying therapeutic targets that are unique to EMT/cancer stem cells. We expressed the EMT transcription factors, Twist, Snail and Slug in HMLE human mammary epithelial cells, and compared their gene expression with parental cells. We identified kinases that are more differentially regulated between the epithelial and mesenchymal cell state.

ORGANISM(S): Homo sapiens

SUBMITTER: Wai Leong Tam

PROVIDER: E-GEOD-43495 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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RNA-seq of two human mammary epithelial cell lines (HMLE and HMLE-Twist-ER) treated with 4-hydroxytamoxifen vs control

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Systems level analysis of epithelial to mesenchymal transition reveals more alteration in phosphoproteome than proteome and identifies DNAJB4 and CD81 as EMT regulators

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The invasion promoter Slug is a critical cell cycle regulator

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2012-02-09 | E-GEOD-35617 | biostudies-arrayexpress

An EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotype.

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2011-10-20 | E-GEOD-29672 | biostudies-arrayexpress

Influence of Slug/SNAI2 on global gene expression in CRC cells and tumors

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2022-06-11 | E-MTAB-11812 | biostudies-arrayexpress

TWIST1-induced microRNA-424 drives an intermediate epithelial-to-mesenchymal transition that opposes metastasis

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2015-02-26 | GSE58560 | GEO

Network Understanding of SNAIL inhibitor induced perturbations in EMT models

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