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Activation of beta-catenin in hepatocellular carcinoma (HCC patients)

ABSTRACT: CTNNB1 is the most frequently mutated gene in hepatocellular carcinoma (HCC). However, its clinical relevance remains controversial. We determined an evolutionarily conserved β-catenin signature by comparative analysis of gene expression data from human HCC and a mouse model (GSE43628). We generated gene expression data from the tumors of 88 HCC patients who underwent surgical resection as the primary treatment. We used these gene expression data to develop a new prognostification model for prognosis of HCC after surgery. We generated gene expression data from the tumors of 88 HCC patients who underwent surgical resection as the primary treatment.

ORGANISM(S): Homo sapiens

SUBMITTER: Sangbae Kim

PROVIDER: E-GEOD-43619 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Activating CAR and β-catenin induces uncontrolled liver growth and tumorigenesis.

Dong Bingning B Lee Ju-Seog JS Park Yun-Yong YY Yang Feng F Xu Ganyu G Huang Wendong W Finegold Milton J MJ Moore David D DD

Nature communications 20150209

Aberrant β-catenin activation contributes to a third or more of human hepatocellular carcinoma (HCC), but β-catenin activation alone is not sufficient to induce liver cancer in mice. Differentiated hepatocytes proliferate upon acute activation of either β-catenin or the nuclear xenobiotic receptor CAR. These responses are strictly limited and are tightly linked, since β-catenin is activated in nearly all of the CAR-dependent tumours generated by the tumour promoter phenobarbital. Here, we show t ...[more]

PMID: 25661872

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