Unknown,Transcriptomics,Genomics,Proteomics

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Identification of nucleosome positions at hox TSSs during zebrafish early embryonic development


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Danio rerio

SUBMITTER: Steven Weicksel 

PROVIDER: E-GEOD-43758 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Dynamic nucleosome organization at hox promoters during zebrafish embryogenesis.

Weicksel Steven E SE   Xu Jia J   Sagerström Charles G CG  

PloS one 20130509 5


Nucleosome organization at promoter regions plays an important role in regulating gene activity. Genome-wide studies in yeast, flies, worms, mammalian embryonic stem cells and transformed cell lines have found well-positioned nucleosomes flanking a nucleosome depleted region (NDR) at transcription start sites. This nucleosome arrangement depends on DNA sequence (cis-elements) as well as DNA binding factors and ATP-dependent chromatin modifiers (trans-factors). However, little is understood about  ...[more]

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