Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Kurinji Pandiyan
PROVIDER: E-GEOD-43851 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Pandiyan Kurinji K You Jueng Soo JS Yang Xiaojing X Dai Chao C Zhou Xianghong J XJ Baylin Stephen B SB Jones Peter A PA Liang Gangning G
Nucleic acids research 20130213 7
DNA methylation inhibitors such as 5-aza-2'-deoxycytidine (5-Aza-CdR) are currently used for the treatment of myelodysplastic syndrome. Although global DNA demethylation has been observed after treatment, it is unclear to what extent demethylation induces changes in nucleosome occupancy, a key determinant of gene expression. We use the colorectal cancer cell line HCT116 as a model to address this question and determine that <2% of regions demethylated by 5-Aza-CdR treatment assume an open config ...[more]