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RNA sequencing of SHP -/- knockout mouse transcriptome

ABSTRACT: Goal of this study is to identify annotated and non-annotated genes transcriptionally regulated by small heterodime partner (SHP, Nrob2) expression. Liver 5' capped RNA samples from three SHP -/- and three wild type mice were sequenced with Illumina GAII sequencer.

ORGANISM(S): Mus musculus

SUBMITTER: Don Delker

PROVIDER: E-GEOD-43893 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genome-wide transcriptome analysis identifies novel gene signatures implicated in human chronic liver disease.

Smalling Rana V RV Delker Don A DA Zhang Yuxia Y Nieto Natalia N McGuiness Michael S MS Liu Shuanghu S Friedman Scott L SL Hagedorn Curt H CH Wang Li L

American journal of physiology. Gastrointestinal and liver physiology 20130627 5

The molecular mechanisms behind human liver disease progression to cirrhosis remain elusive. Nuclear receptor small heterodimer partner (SHP/Nr0b2) is a hepatic tumor suppressor and a critical regulator of liver function. SHP expression is diminished in human cirrhotic livers, suggesting a regulatory role in human liver diseases. The goal of this study was to identify novel SHP-regulated genes that are involved in the development and progression of chronic liver disease. To achieve this, we cond ...[more]

PMID: 23812039

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RNA sequencing of SHP -/- knockout mouse transcriptome

Project description:Goal of this study is to identify annotated and non-annotated genes transcriptionally regulated by small heterodime partner (SHP, Nrob2) expression.

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Concomitant deletion of Shp-1 and Shp-2 in T cells fails to improve anticancer responses

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SHP-1 regulates transcription of PCK1 to control gluconeogenesis

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A Themis:SHP complex promotes T cell survival

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2015-01-07 | PXD001410 | Pride

Feeding activates FGF15-SHP-TFEB-mediated lipophagy in the gut

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