Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Thomas Lukas
PROVIDER: E-GEOD-4390 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Lukas Thomas J TJ Luo Wei Wei WW Mao Haihong H Cole Natalie N Siddique Teepu T
Molecular & cellular proteomics : MCP 20060329 7
One of the causes of amyotrophic lateral sclerosis (ALS) is due to mutations in Cu,Zn-superoxide dismutase (SOD1). The mutant protein exhibits a toxic gain of function that adversely affects the function of neurons in the spinal cord, brain stem, and motor cortex. A proteomic analysis of protein expression in a widely used mouse model of ALS was undertaken to identify differences in protein expression in the spinal cords of mice expressing a mutant protein with the G93A mutation found in human A ...[more]