Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

H3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Agustin Chicas 

PROVIDER: E-GEOD-43922 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

altmetric image

Publications

H3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence.

Chicas Agustin A   Kapoor Avnish A   Wang Xiaowo X   Aksoy Ozlem O   Evertts Adam G AG   Zhang Michael Q MQ   Garcia Benjamin A BA   Bernstein Emily E   Lowe Scott W SW  

Proceedings of the National Academy of Sciences of the United States of America 20120521 23


Cellular senescence is a tumor-suppressive program that involves chromatin reorganization and specific changes in gene expression that trigger an irreversible cell-cycle arrest. Here we combine quantitative mass spectrometry, ChIP deep-sequencing, and functional studies to determine the role of histone modifications on chromatin structure and gene-expression alterations associated with senescence in primary human cells. We uncover distinct senescence-associated changes in histone-modification pa  ...[more]

Similar Datasets

2013-01-31 | E-GEOD-43920 | biostudies-arrayexpress
2013-01-31 | E-GEOD-43921 | biostudies-arrayexpress
2012-08-25 | E-GEOD-40349 | biostudies-arrayexpress
2011-10-26 | E-GEOD-31967 | biostudies-arrayexpress
2011-10-26 | E-GEOD-31968 | biostudies-arrayexpress
2016-09-08 | E-GEOD-62827 | biostudies-arrayexpress
2011-10-26 | E-GEOD-31966 | biostudies-arrayexpress
2016-02-23 | E-GEOD-78138 | biostudies-arrayexpress
2014-05-19 | E-GEOD-50479 | biostudies-arrayexpress
2016-02-22 | E-GEOD-78142 | biostudies-arrayexpress