Genome-wide characterization of gene expression variations and DNA copy number changes in prostate cancer cell lines

ABSTRACT: This SuperSeries is composed of the following subset Series: GSE4016: Gene expression variations in prostate cancer cell lines GSE4017: DNA copy number changes in prostate cancer cell lines Abstract: BACKGROUND: The aim of this study was to characterize gene expression and DNA copy number profiles in androgen sensitive (AS) and androgen insensitive (AI) prostate cancer cell lines on a genome-wide scale. METHODS: Gene expression profiles and DNA copy number changes were examined using DNA microarrays in eight commonly used prostate cancer cell lines. Chromosomal regions with DNA copy number changes were identified using cluster along chromosome (CLAC). RESULTS: There were discrete differences in gene expression patterns between AS and AI cells that were not limited to androgen-responsive

ORGANISM(S): Homo sapiens

SUBMITTER:  

PROVIDER: E-GEOD-4396 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress