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MiRNA in human lung fibroblasts

ABSTRACT: By employing miRCURY™ LNA array, we have identified a subset (79) of the total number of miRNAs that are differentially expressed in TGF beta1-treated human lung fibroblasts MRC-5 cells, as compared to untreated control cells To know the differential expression of miRNA in human lung fibroblasts after treatment of TGF beta1

ORGANISM(S): Homo sapiens

SUBMITTER: Gang Liu 

PROVIDER: E-GEOD-43992 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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miR-145 regulates myofibroblast differentiation and lung fibrosis.

Yang Shanzhong S   Cui Huachun H   Xie Na N   Icyuz Mert M   Banerjee Sami S   Antony Veena B VB   Abraham Edward E   Thannickal Victor J VJ   Liu Gang G  

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20130301 6

The expression of smooth muscle actin-α (SMA-α) by fibroblasts defines phenotypic transition to myofibroblasts and is a primary contributor to contractile force generation by these differentiated cells. Although the regulation of SMA-α expression has been the focus of many studies, there is presently only limited information concerning miRNA regulation of lung myofibroblast differentiation and the involvement of these miRNAs in pulmonary fibrosis. To determine the role of miR-145 in regulating l  ...[more]

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